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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK5
All Species:
43.03
Human Site:
S276
Identified Species:
67.62
UniProt:
Q00535
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00535
NP_004926.1
292
33304
S276
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
Chimpanzee
Pan troglodytes
XP_001149427
306
35062
T277
Y
D
P
S
Q
R
I
T
A
K
T
A
L
A
H
Rhesus Macaque
Macaca mulatta
XP_001102502
306
34957
T277
Y
D
P
S
R
R
I
T
A
K
T
A
L
A
H
Dog
Lupus familis
XP_532760
331
37322
S315
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
Cat
Felis silvestris
Mouse
Mus musculus
P49615
292
33270
S276
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
Rat
Rattus norvegicus
Q03114
292
33236
S276
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001129258
292
33321
S276
V
H
P
V
Q
R
I
S
A
E
E
A
L
Q
H
Frog
Xenopus laevis
P51166
292
33320
C276
C
N
P
V
Q
R
I
C
A
D
E
A
L
Q
H
Zebra Danio
Brachydanio rerio
NP_571794
292
33381
S276
C
N
P
V
Q
R
I
S
A
E
E
A
L
Q
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P48609
294
33162
S276
C
R
P
N
Q
R
I
S
A
E
A
A
M
Q
H
Honey Bee
Apis mellifera
XP_391878
299
34094
S276
C
N
P
A
L
R
L
S
A
D
E
A
M
A
H
Nematode Worm
Caenorhab. elegans
NP_499783
292
33044
D276
C
N
P
A
G
R
I
D
A
D
A
A
L
R
H
Sea Urchin
Strong. purpuratus
XP_001200386
295
33676
S277
C
N
P
A
L
R
M
S
A
E
E
G
L
M
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
T277
Y
E
P
S
K
R
I
T
A
R
Q
A
L
E
H
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
N277
M
D
P
T
K
R
I
N
A
R
A
A
L
E
H
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
59.1
58.8
86.7
N.A.
99.6
99.3
N.A.
N.A.
97.2
96.9
96.5
N.A.
77.5
81.9
73.6
67.1
Protein Similarity:
100
75.1
75.1
87.9
N.A.
100
99.6
N.A.
N.A.
98.9
98.9
98.9
N.A.
86.7
89.3
86.9
78.9
P-Site Identity:
100
53.3
46.6
100
N.A.
100
100
N.A.
N.A.
86.6
86.6
100
N.A.
73.3
60
60
66.6
P-Site Similarity:
100
73.3
73.3
100
N.A.
100
100
N.A.
N.A.
93.3
93.3
100
N.A.
80
80
73.3
73.3
Percent
Protein Identity:
N.A.
57.8
N.A.
56.4
N.A.
N.A.
Protein Similarity:
N.A.
76.8
N.A.
75.5
N.A.
N.A.
P-Site Identity:
N.A.
46.6
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
N.A.
73.3
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
20
0
0
0
0
100
0
20
94
0
20
0
% A
% Cys:
67
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
0
20
0
0
0
0
0
7
0
20
0
0
0
0
0
% D
% Glu:
0
7
0
0
0
0
0
0
0
54
60
0
0
14
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
7
0
0
0
0
0
0
7
0
0
0
% G
% His:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
100
% H
% Ile:
0
0
0
0
0
0
87
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
14
0
0
0
0
14
0
0
0
0
0
% K
% Leu:
0
0
0
0
14
0
7
0
0
0
0
0
87
0
0
% L
% Met:
7
0
0
0
0
0
7
0
0
0
0
0
14
7
0
% M
% Asn:
0
60
0
7
0
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
60
0
0
0
0
0
7
0
0
54
0
% Q
% Arg:
0
7
0
0
7
100
0
0
0
14
0
0
0
7
0
% R
% Ser:
0
0
0
20
0
0
0
60
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
7
0
0
0
20
0
0
14
0
0
0
0
% T
% Val:
7
0
0
47
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
20
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _